Ipamorelin 10mg

What is Ipamorelin?

Ipamorelin is a selective growth hormone secretagogue — a peptide that stimulates the pituitary gland to release growth hormone (GH) in a natural, pulsatile manner. Unlike some GH-releasing compounds, Ipamorelin is highly selective, meaning it stimulates GH release without significantly raising cortisol or prolactin levels.

Buy Ipamorelin in Canada from Peptide Clinique — laboratory-grade, 99%+ purity, ISO-certified source, with fast domestic shipping.

How Does Ipamorelin Work?

Ipamorelin works by mimicking ghrelin and binding to the GHSR (growth hormone secretagogue receptor) in the pituitary gland. This triggers a clean pulse of growth hormone release — closely mimicking the body’s natural GH rhythms. Because it is selective, it does not cause the unwanted spikes in hunger, cortisol, or prolactin that some other GH peptides produce.

Key Research Benefits

• Growth hormone stimulation — clean, selective GH pulses
• Anti-aging properties — studied for age-related GH decline
• Muscle preservation and growth — supports lean body composition
• Fat metabolism — GH elevation supports fat burning research
• Improved sleep quality — GH is primarily released during deep sleep
• Bone density support — studied in models of osteoporosis prevention
• Recovery acceleration — enhanced tissue repair via GH pathways

Research Dosage Guidelines

User Profile	Suggested Research Dose	Frequency
Beginner researcher	100–150 mcg	Once daily (before sleep)
Intermediate researcher	150–300 mcg	1–2 times daily
Advanced researcher	300–500 mcg	2–3 times daily
Anti-aging research models (40–65+)	100–200 mcg	Once daily at night

Best administered before sleep to align with the body’s natural GH release cycle. Reconstitute with bacteriostatic water.

Frequently Asked Questions

Is Ipamorelin safe for anti-aging research?

Ipamorelin is considered one of the gentlest GH secretagogues in research, with minimal side effects observed at standard doses. It is frequently studied in aging models due to its selective and mild profile.

Can I buy Ipamorelin in Canada?

Yes. Ipamorelin is available as a research peptide in Canada. Peptide Clinique provides high-purity Ipamorelin with discreet, fast shipping.

⚠️ For Research Use Only. Not intended for human consumption. Must be handled by qualified researchers.

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Category: Growth Hormone

Often researched with: Tesamorelin | Bacteriostatic Water

← View all Growth Hormone peptides

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Product Information

Purity	99%+
Form	Lyophilized Powder
Administration	Subcutaneous Injection
Storage	Keep Refrigerated at 2°C–8°C
MFG Date	01/01/2026
Expiry Date	01/01/2030

⚠️ FOR RESEARCH PURPOSES ONLY — Not intended for human consumption.

About Ipamorelin: A Comprehensive Research Overview

Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) that acts as a selective growth hormone secretagogue (GHS) by binding the ghrelin receptor (GHS-R1a). It was developed in the late 1990s by Novo Nordisk as part of a programme to identify GH-releasing compounds with cleaner pharmacological profiles than earlier secretagogues such as GHRP-6. Ipamorelin’s defining characteristic is its high selectivity: it stimulates GH release from the pituitary with minimal co-release of cortisol, ACTH, aldosterone, or prolactin—side effects that had limited earlier-generation GHSs in research applications.

Our Ipamorelin 10mg is supplied as a lyophilised white powder of ≥99% purity, confirmed by HPLC and mass spectrometry. Each batch has a downloadable Certificate of Analysis.

Research Background and Development History

The discovery of ghrelin in 1999 and the characterisation of GHS-R1a provided a retroactive explanation for how synthetic secretagogues like ipamorelin exert their effects—by mimicking ghrelin’s action at the same receptor. Prior to ghrelin’s discovery, the receptor was known as the GH-secretagogue receptor, identified through the binding of earlier synthetic ligands. Ipamorelin was among the most potent and selective compounds developed against this receptor during that era, making it a key research tool for understanding GH axis physiology.

The 1998 publication by Raun et al. in the European Journal of Endocrinology characterising ipamorelin’s pharmacological profile remains a foundational reference. It demonstrated that ipamorelin produced GH pulses comparable in amplitude to those elicited by GHRP-6 but without the cortisol and adrenocorticotropic hormone (ACTH) co-stimulation, establishing the cleaner selectivity profile that has made ipamorelin a preferred GHS research tool since.

Mechanism of Action

GHS-R1a Agonism

Ipamorelin binds and activates the GHS-R1a receptor expressed on somatotroph cells in the anterior pituitary. This receptor is coupled to Gq/11 protein signalling, leading to phospholipase C activation, inositol trisphosphate (IP₃) generation, and intracellular calcium release. The calcium transient triggers exocytosis of GH-containing secretory granules from pituitary somatotrophs, producing a rapid pulse of GH into circulation. Ipamorelin’s selectivity for somatotrophs—relative to corticotrophs (ACTH/cortisol) or other pituitary cell types—explains its clean side-effect profile compared to earlier GHSs.

Synergy with GHRH Analogues

Ipamorelin acts through a mechanistically distinct pathway from growth hormone-releasing hormone (GHRH), which activates cAMP/PKA signalling via Gs-coupled receptors. Combining a GHS-R1a agonist (ipamorelin) with a GHRH analogue (such as CJC-1295 or tesamorelin) therefore engages two independent pituitary GH-release pathways simultaneously, producing substantially greater GH pulses than either compound alone—a phenomenon well-documented in rodent and human studies. This mechanistic synergy is the rationale behind the commonly studied ipamorelin + CJC-1295 research combination.

IGF-1 Stimulation

GH released in response to ipamorelin stimulates hepatic IGF-1 (insulin-like growth factor-1) production. IGF-1 mediates many of GH’s downstream anabolic effects, including nitrogen retention, protein synthesis, lipolysis, and cellular proliferation. In animal studies, ipamorelin administration has been associated with increased lean body mass, reduced fat mass, and improved bone mineral density—effects attributed to the GH-IGF-1 axis activation.

Gastrointestinal Motility

GHS-R1a is also expressed throughout the gastrointestinal tract, and ghrelin/GHS-R1a agonists have known prokinetic effects. Research has investigated ipamorelin in post-operative ileus models, with data suggesting it accelerates GI motility recovery after surgery—an application area distinct from its GH-axis effects.

Purity, Quality, and Analytical Testing

• HPLC Purity: ≥99% — chromatographic purity of the pentapeptide
• Mass Spectrometry: Confirms molecular weight (711.9 Da) and correct amino acid sequence
• Endotoxin (LAL) testing: Below research-grade acceptance limits
• Sterility testing: Standard microbiological protocol
• Counter-ion content: Acetate salt form verified

Full COA available at Certificates of Analysis.

Storage Instructions

• Lyophilised: Store at −20 °C, protected from light and moisture. Shelf life up to 24 months.
• Reconstituted: Refrigerate at 2–8 °C. Use within 28 days. Avoid freeze-thaw cycles.
• Sensitivity: Protect from humidity; lyophilised peptide vials should be allowed to reach room temperature before opening to prevent moisture condensation on the powder.

Reconstitution Guide

1. Warm the sealed vial to room temperature before opening (5–10 minutes).
2. Disinfect the rubber stopper with isopropyl alcohol. Air-dry.
3. Using a sterile syringe, inject bacteriostatic water slowly along the vial wall.
4. Gently swirl until completely dissolved. The solution should be clear and colourless.
5. Record reconstitution date and concentration on the label.

Refer to the Dosage Guide for concentration and volume calculations.

Who Researches Ipamorelin?

• Endocrinology researchers studying GH pulse dynamics, GH deficiency models, and GHS-R1a pharmacology
• Ageing and longevity labs investigating GH-axis decline with age and its consequences for body composition
• Body composition researchers studying lean mass preservation and fat reduction in animal models
• Bone biology groups exploring GH/IGF-1 axis effects on bone mineral density and fracture healing
• GI motility researchers studying post-operative ileus and gastroparesis models

Research use only. Not for human consumption.

Related Products

• Tesamorelin 5mg — GHRH analogue that works synergistically with GHS-R1a agonists like ipamorelin for enhanced GH release in research models
• CJC-1295 + Ipamorelin blend — Pre-formulated combination available in our Shop for researchers studying the dual-pathway GH stimulation protocol

Explore our full catalogue at Shop.